20 Vesey Street is located in lower Manhattan, a short walk from 26 Federal Plaza. It is right near Ground Zero, between Church Street and Broadway. It is just south of both the Brooklyn Bridge and the Holland Tunnels.
 
The nearest subways to 20 Vesey Street are as follows:
E: World Trade Center
2, 3: Park Place
4, 5, J, M, Z: Fulton Street
A, C: Chambers Street
R, W: City Hall